Forward facing shot of 3 tall margarita glasses filled with a deep reddish pink margarita and crushed ice and limes scattered around and a copper shaker and glass of watermelon juice in the background

Watermelon Grapefruit Margaritas

These Watermelon Grapefruit Margaritas are made with fresh watermelon juice, freshly squeezed grapefruit juice, lime juice, tequila (obviously), orange liqueur, and a touch of simple syrup for sweetness! Such a perfect, refreshing summertime cocktail! 

Course Beverage, Cocktail, Drink
Prep Time 10 minutes
Servings 1 cocktail, is easily multiplied
Author Molly | Spices in My DNA


  • 1 1/2 ounces tequila
  • 1/2 ounce Grand Marnier
  • 1 1/2 ounces freshly squeezed lime juice
  • 1 ounce freshly squeezed grapefruit juice
  • 2 1/2 ounces fresh watermelon juice*
  • 1 ounce simple syrup*
  • salt for rimming the glass
  • lime slices for garnish
  • grapefruit slices for garnish
  • watermelon slices for garnish


  1. Moisten the edge of your glass with a lime wedge and rim in salt. Fill the glass with crushed ice. Add a few ice cubes to a cocktail shaker and add the tequila, Grand Marnier, lime juice, grapefruit juice, watermelon juice, and simple syrup. Shake for 20-30 seconds and pour in the glass. Garnish with a lime slice, grapefruit slice, and a watermelon slice. Enjoy!

Recipe Notes

*For the simple syrup, bring 1 cup water to a boil in a medium saucepan. Once boiling, add 1 cup sugar and stir for 30 seconds or until dissolved. Remove from heat and let cool completely.
*To make watermelon juice, cut up a watermelon into cubes (discard the rind), add to a blender, and blend until smooth. Strain through a fine mesh strainer and voila! I used one baby watermelon which was about 7 cups of watermelon, and it made a ton of extra juice.
*Makes a lot of extra simple syrup. Will keep in the fridge for up to 2 weeks!
*If you want to make these pitcher-style for a crowd, I'd measure all of the margarita ingredients out for how many people you want to make them for, add everything to a pitcher, and chill the mixture in the fridge. When you're ready to serve, add the crushed ice, and serve!